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  • 09월 20일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제126회 대한화학회 학술발표회 및 총회 Aggregation-Induced Emission based turn-on probe Tetrazine-Kaleidolizine

등록일
2020년 9월 3일 16시 52분 11초
접수번호
0797
발표코드
ORGN.P-379 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 21일(수) 17:00~17:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Sang-Kee Choi, Seulbi Lee, Eunha Kim*
Department of Molecular Science and Technology, Ajou University, Korea
Indolizine based fluorophore Kaleidolizine(KIz) is known as tuning the emission wavelength by changing its substituents. The KIz can offer a clear view with low background signal, and an increased signal-to-noise (S/N) ratio, which is ideal for biosensing and bioimaging because of its property of Aggregation-Induced Emission(AIE). Additionally, the well-known fluorescent quencher tetrazine is applied as the substituent of KIz to act both as a reactive handle and quencher moiety. Tetrazine is having attention with its fast and chemoselective [4+2] cycloaddition with specific dienophiles such as Trans-cyclooctene(TCO) without any catalysts. With high selective ‘tagging’ of specific targets, which is called click chemistry[1], it can provide a means to image or track the components and interactions. As the quenched fluorophore, the tetrazine-modified KIz implies with various application methods by lowering the background signal to enhance the turn-on ratio.

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