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  • 09월 20일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제126회 대한화학회 학술발표회 및 총회 Simultaneous and visual detection of cysteamine based on Michael addition reaction with polydiacetylenes

등록일
2020년 9월 3일 17시 01분 41초
접수번호
0830
발표코드
ORGN.P-382 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 21일(수) 17:00~17:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Seongman Lee, Thanh Chung Pham, Songyi Lee1,*
Department of Industry 4.0 Convergence Bionics Engineering, Pukyong National University, Korea
1Department of Chemistry, Pukyong National University, Korea
We report fabrication of a highly sensitive colorimetric and fluorometric sensor comprising a self-assembled polydiacetylene (PDA) liposome for the measurement of cysteamine concentration. N-maleimidomethanol (HM) moiety was used as Michael addition acceptor, which reacts with the thiol groups in cysteamine to generate maleimide-thiol conjugation resulting in conformational transition of the conjugated backbone. Further, this chemosensor system displays a clear blue-to-red colorimetric transition in the presence of cysteamine among various biothiols with high selectivity and sensitivity owing to the the structural specificity of Cysteamine.The resulting PDA solutions were analyzed via FE-SEM, UV-vis, fluorescence and Raman spectroscopies, and chromoisomerism for naked-eye visualization. This chemosensor provides a convenient method for the detection of cysteamine in aquatic solution and in real samples.

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