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  • 09월 23일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제126회 대한화학회 학술발표회 및 총회 Development of HDAC Inhibitors for Treatment of Inflammatory Bowel Disease

등록일
2020년 9월 8일 14시 49분 28초
접수번호
0887
발표코드
ORGN1-3 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
화 11시 : 35분
발표형식
심포지엄
발표분야
Organic Chemistry - Current Trends in Organic Chemistry I: Medicinal Chemistry & Chemical Biology
저자 및
공동저자
Jonghoon Kim
Department of Chemistry, Soongsil University, Korea

Epigenetic alterations have been involved in the pathogenesis of cancer and auto-immune diseases, including Crohn’s Disease, Ulcerative Colitis, Lupus and Rheumatoid Arthritis. Histone deacetylases (HDACs), a key component of the epigenetic machinery, are enzymes that catalyze the removal of acetyl functional groups from the lysine residues of both histone and non-histone proteins. There are 18 isotypes of HDACs with different functions in different disease settings. Therefore, the development of HDAC inhibitor with isoform-selectivity may provide important new tools for treatment of auto-immune diseases. To date, MC-1568 (MJK001) analogues were designed and synthesized to target HDAC9 for treatment of inflammatory bowel disease (IBD), one of the auto-immune diseases


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