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  • 09월 20일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제126회 대한화학회 학술발표회 및 총회 Pd-catalyzed selective γ-arylation of aliphatic amines with transient directing groups

등록일
2020년 9월 11일 14시 26분 52초
접수번호
1047
발표코드
ORGN.P-401 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 21일(수) 17:30~18:00
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Hyeon Bin Ha, HoJeong Choi, Jaesung Kwak1, Byunghyuck Jung2, Min Kim*
Department of Chemistry, Chungbuk National University, Korea
1Infectious Diseases Therapeutic Research Center, Korea Research Institute of Chemical Technology, Korea
2School of Basic Science, Daegu Gyeongbuk Institute of Science & Technology, Korea
Pd-catalyzed γ-position sp3-C-H arylation of primary amines bearing an aliphatic chain or cycloalkyl substituent have been developed with transient directing group (TDG) strategy, and its mechanism has been proposed with computational studies, metalated intermediates, and kinetic isotope effect (KIE) studies. The catalytic development with TDG has been intensively studied for various transformation including C-H bond activations. 1 In this study, 2-hydroxybenzaldehyde derivative plays a key role as a TDG in γ-position sp3-C-H arylation to assist the selective and efficient C–H activation of a Pd catalyst. Furthermore, the development of tandem reaction to transform 1O-amines into β-aryl substituted ketones demonstrates the synthetic utilities. Detail catalytic conditions, substrate scopes, DFT calculation for mechanism, X-ray structure of palladacycle compound, and result of KIE study will be discussed during the presentation.

Reference
1. H. Ha, J. Lee, M. H. Park*, B. Jung*, M. Kim. Bull. Kor. Chem. Soc. 2020, 41, 582.

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