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  • 09월 20일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제126회 대한화학회 학술발표회 및 총회 Cu(I)-Catalyzed Enantioselective [5 + 1] Cycloaddition of N‑Aromatic Compounds and Alkynes via Chelating-Assisted 1,2-Dearomative Addition

등록일
2020년 9월 15일 11시 28분 10초
접수번호
1061
발표코드
ORGN.P-402 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 21일(수) 17:30~18:00
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Donguk Ko, Eun Jeong Yoo*
Department of Applied Chemistry, Kyung Hee University, Korea

[m + n] Cycloadditions are one of the most powerful methods for the construction of polycyclic N- heterocycles which are the core skeletons in enormous number of natural products and biologically active compounds. Especially, the asymmetric hetero Diels-Alder reaction, representative [4 + 2] cycloaddition, is one of the most powerful strategy for optically active six-membered heterocyclic compounds in a single operation. Our group has disclosed that an N-aromatic zwitterion with unusual charge distribution could serve as a five-atom donor, leading to the development of many [5 + n] cycloadditions for medium-sized heterocycles. In this symposium, we will discuss the asymmetric copper-catalyzed [5 + 1] cycloaddition of quinolinium zwitterions and terminal alkynes, resulting in the formation of optically pure six-membered ring systems. The developed cycloaddition to six-membered adducts is characterized by high stereoselectivity and good functional group tolerance, and thus has sufficient potential as a surrogate of asymmetric hetero Diels-Alder reaction.


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