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대한화학회 창립 75주년
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09월 20일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능
제126회 대한화학회 학술발표회 및 총회
Metal-based complexes for multidrug-resistant pathogens: Synthesis, characterization and biological applications
2020년 9월 17일 09시 36분 52초
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10월 21일(수) 17:30~18:00
, Atakilt Abebe
, Moges Abebe
, Misganaw Liyew
Chemistry Department, Science College, Bahir Dar University, Ethiopia
Bioinorganic Chemistry, Science College, Bahir Dar University, Ethiopia
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The intensive use of antibiotics has led to an increase in drug-resistant bacteria against known antibiotics. To overcome the alarming problem of microbial resistance to antibiotics, the discovery of novel active compounds against new targets is a matter of urgency. Based on this, we report, three new mixed ligand complexes of cobalt(II) viz. mononuclear ([Co(phen)2(Act)(H2O)]Cl2.H2O and [Co(phen)2(Act)(en)]Cl2), and binuclear [Co2(phen)4(Act)2(en)]Cl4 which were synthesized from CoCl2.6H2O, 1,10-phenanthroline monohydrate, acetamide, and ethylenediamine.
In the first step, the precursor complex was synthesized from cobalt chloride salt and 1,10-phenanthroline, then the precursor complex was treated with acetamide to give the [Co(phen)2(Act)(H2O)]Cl2.H2O complex. Finally, the ([Co(phen)2(Act)(H2O)]Cl2.H2O complex was treated in different stoichiometry separately with one and two moles of ethylenediamine resulting the corresponding mononuclear and binuclear Co(II) complexes, respectively. All the complexes were synthesized in methanol media, through refluxing under controlled reaction conditions. The synthesized complexes were characterized using spectroscopic (ESI-MS, ICP-OES, FT-IR, and UV-Vis), chloride determination as well as melting point and conductance measurement. In vitro antibacterial activity was also tested on two Gram-positive (Staphylococcus aureus, Streptococcus pyogenes) and two Gram-negative (Escherichia coli and Klebsiella pneumoniae) bacteria using the disc diffusion method and compared with the standard commercially available drug, Gentamicin.
All the synthesized Co(II) complexes were proposed octahedral geometry and showed moderate to high antibacterial activity. The complexes demonstrated appreciable activity even against the Gram-negative bacteria. The antibacterial result was found comparable with the commercial drug Gentamicin even at a lower concentration of complexes.
The results indicated that the synthesized complexes may be considered as potential antibacterial agents after passing cytotoxicity testing.
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