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  • 09월 23일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제126회 대한화학회 학술발표회 및 총회 Resin Functionalization with Protein N-Termini and Metal-Chelating Ligands

등록일
2020년 9월 17일 15시 21분 50초
접수번호
1157
발표코드
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발표시간
화 14시 : 45분
발표형식
심포지엄
발표분야
Polymer Chemistry - Recent Trends in Early-career Polymer Chemists
저자 및
공동저자
Byungjin Koo, Matthew Francis1,*
Department of Polymer Science and Engineering, Dankook University, Korea
1Chemistry, University of California, Berkeley, United States
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승인 1건
Resin beads are granular crosslinked polymers. Their chemical modification has enabled scientific and industrial advances, such as combinatorial synthesis and the separation and purification of complex liquids. In this talk, two types of chemically modified resins are presented. First, we report functional proteins that are site-selectively immobilized on polymeric resin. Specifically, we employ an N-terminal protein modification strategy using an N-terminus-targeting reagent, 2-pyridinecarboxyaldehyde (2PCA), on resin through an imidazolidinone linkage. Seven different types of native proteins are N-terminally modified on resin with a high loading of proteins, and their utility to capture toxic hormones through protein-ligand interactions in water is underway. Second, polystyrene resin is functionalized with oligoethylene glycols (OEG). In spite of the widespread applications of ethylene glycol-type molecules, we found that the oligoethylene glycols can bind to lithium and cobalt with the different affinity. The mixture of lithium and cobalt in acetonitrile can be separated in a chromatographic column that is packed with the OEG-resin, and we envision that these materials can be used in the recycling of lithium ion batteries to extract metal components such as lithium and cobalt.

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