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학술발표회초록보기

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  • 09월 23일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제126회 대한화학회 학술발표회 및 총회 Catalytic Enantioselective Cyclopropanation and Tandem Rearrangement

등록일
2020년 9월 18일 17시 38분 59초
접수번호
1179
발표코드
ORGN3-1 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
화 15시 : 00분
발표형식
심포지엄
발표분야
Organic Chemistry - Joint Organic Chemistry Symposium: Basic Research Lab
저자 및
공동저자
Do Hyun Ryu
Department of Chemistry, Sungkyunkwan University, Korea
The proton-activated chiral oxazaborolidinium ion (COBI) catalyst, which can activate various carbonyl compounds such as aldehydes, ketones, acroleins, and enones through Lewis acid-base interactions and synergistic hydrogen bonds, facilitates asymmetric 1,2- or 1,4-carbonyl additions of nucleophiles. Nucleophilic 1,4-addition of diazo compounds and chemoselective ring-closure afforded an efficient approach to cyclopropanes; and their tandem rearrangements provided four- five and seven-membered cyclic compounds with excellent stereoselectivity. In this talk, our recent studies on COBI-catalyzed enantioselective domino reactions of diazo compounds will be presented. Logical mechanistic explanations of asymmetric COBI catalysis will be also discussed.

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