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  • 03월 07일 12시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Bing Affinities of 3-Substituted-1H-quinazoline-2,4-diones as 5-HT6 receptor antagonists

등록일
2007년 2월 13일 12시 52분 12초
접수번호
1138
발표코드
30P210포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅳ>
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
박철민, 박우규1, 성철민2, 박지민
한국화학연구원 중추신경계연구팀,
1한국화학연구원 신약기반기술연구센터,
2한국화학연구원 생명화학연구단,
The serotonin (5-HT) superfamily of receptors currently consists of seven classes (5-HT1-7) that include approximately fourteen human subclasses. The 5-HT6 receptor is one of the most recently identified serotonin receptors and is positively coupled to the adenylate cyclase secondary messenger system. The CNS localization of the 5-HT6 receptors and their affinity for CNS drugs have sparked considerable effort to understand the role of this receptor in treatment of CNS disorder, including schizophrenia, depression, and impaired learning and memory. As a part of ongoing work aimed at the discovery of new 5-HT6 receptor antagonists, novel classes of N-substituted-1H-quinazoline-2,4-dione were designed, synthesized and identified to exhibit high binding affinity for 5-HT6 receptors. This presentation will discuss the preparation and binding affinities of 3-substituted-1H-quinazoline-2,4-diones which show high binding affinity towards the 5-HT6 receptors.

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