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  • 09월 05일 23시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제128회 대한화학회 학술발표회, 총회 및 기기전시회 Frontiers in Sequencing and Imaging-based Methodologies for Single-cell Analysis

2021년 8월 9일 20시 07분 32초
PHYS2-3 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 09시 : 40분
Physical Chemistry - Recent Advances in Physical Chemistry
저자 및
Chang Ho Sohn
Advanced Science Institute, Yonsei University, Korea
All cells are different. Starting from the same genetic information, every cell functions differently but harmoniously, together in place via cell-cell interactions. In diseases, such functions are disrupted and cells behave abnormally with high heterogeneity. To understand diseases such as cancers that possess highly diverse genetic features, it is important to investigate their heterogeneity at the single-cell level. Recent advances in single-cell analyses by next-generation sequencing and tissue clearing technologies have broadened our understanding about how complex biological systems work. Yet, current single-cell methods are unable to detect isoforms or post-translation modifications of proteins, which play significant roles in cell signaling pathways whose malfunctions often lead to the onset of many diseases. Also, to fully understand the biological status of the samples, investigating both mRNA and proteins in situ is critical. However, consolidated tissue clearing/expansion methodologies for the simultaneous preservation of various tissue features including tissue architectures, fluorescent proteins, antigenicity of proteins, and nucleic acids have not been reported. I will present my recent works in the development of novel single-cell analysis platforms to address the challenges described above and discuss the future directions toward their applications for spatial multi-omics in various biological systems.