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  • 03월 07일 12시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

New Approach for Gene Delivery using Multifunctional Gold Nanoparticles

등록일
2007년 2월 13일 13시 17분 57초
접수번호
1152
발표코드
31P241포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅳ>
발표형식
포스터
발표분야
재료화학
저자 및
공동저자
임원규, 남좌민
서울대학교 화학부,
The development of a gene delivery system with low toxicity, high specificity, and good delivery efficiency is key to gene therapy. Herein, we report a Au nanoparticle(NP)-based gene delivery system with high efficiency, low cytotoxicity and good stability. We transfer plasmid DNA( pDNA), involved with EGFP expression on cell surface, to both eukaryotes and prokaryotes with liposome-coated pDNA-Au-NPs. The results show that more cells are transfected by this liposome-modified DNA-Au-NP probes than any other methods available. We suspect that this is possible because one Au-NP probe carries tens of pDNA, charges and many possible structural conformations of pDNA strands were greatly reduced by putting pDNA strands on Au-NPs, and densely-modified pDNA minimizes the degradation of pDNA by DNAases in a cell.

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