KCS

Coronary artery spasm causes a wide spectrum of ischemic heart diseases, from variant angina(VA) to acute myocardial infarction and even sudden cardiac death. Endothelial nitric oxide synthase (eNOS) catalyzes the synthesis of nitric oxide, which regulates vascular tone, and may be related to coronary vasospasm. This study tried to determine whether eNOS polymorphism is associated with susceptibility to variant angina. We genotyped 92 patients with variant angina, 70 ethnically matched healthy controls by denaturing high performance liquid chromatography (DHPLC) after PCR amplification of the genomic region encompassing the polymorphic site. As a results, there were no evidences for genetic association conferred by the eNOS(G894T and T786C) gene with respect to susceptibility to variant angina in Koreans.