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Analysis of Interleukin-17F to Behcet Disease by DHPLC

등록일
2007년 2월 13일 13시 22분 57초
접수번호
1156
발표코드
28P126포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅳ>
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
조민호, 남윤형, 안영창, 이상현, 서재원, 윤일규, 장원철1, 박수민2
단국대학교 화학과,
1단국대학교 첨단과학대학,
2제넷바이오 연구개발부,
A family of cytokines, IL-17, has recently been defined that reveals a distinct ligand-receptor signaling system. Functional studies have provided evidence for its importance in the regulation of immune responses. We genotyped 113 patients with behcet's disease (BD) and 113 healthy controls for the polymorphisms in IL-17F with PCR-DHPLC methods. Amplified PCR product did comparative analysis by DHPLC, and assorted several kind of patterns by chromatogram of DHPLC. Additionally, two samples for each other patterns confirmed by sequencing. As a results, the overall distribution of alleles was different between behcet's patients and healthy controls. There were evidences for genetic association conferred by the IL-17F gene with bechet's disease (BD).

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