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A Novel Method for Synthesis of Substituted Benzochromenes and Its Application to Naturally Occurring Lapachenol and Mollugin

등록일
2007년 2월 23일 10시 10분 31초
접수번호
1249
발표코드
29P190포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅱ>
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
김윤미, 김정희, 이용록
영남대학교 디스플레이화학공학부,
The molecules with benzochromene (or naphthopyran) moiety are widely distributed in nature. They have shown to have a range of significant biological and pharmacological properties. For example, lapachenol was isolated from Lippia sidoides, which is known as “Alecrim pimenta”, an odoriferous plant that grows wild in the northeastern region of Brazil. The aerial parts of this species are traditionally used as the antiinfective and antiseptic agents which contain thymol and carvacrol as major constituents. They also showed bactericidal and fungicidal activities. Mollugin was isolated from Chinese medicinal plant Rubia cordifolia and has showed potential as antitumor, antimutagenic, and antiviral compounds against the hepatitis B virus. Also mollugin has been shown strong inhibition of arachdonic acid-induced and collagen-induced platelet aggregation. We describe herein a mild and facile methodology for preparation of benzochromene derivatives. By using this methodology as key-step, we also describe concise synthesis of natural products lapachenol and mollugin.

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