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  • 03월 07일 12시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Nanoscale sensing and directed molecular growth

2007년 2월 28일 15시 11분 27초
목18E2심 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 14시 : 20분
재료화학 - 1st Korea-UK Chemistry Workshop: Nanostructured Materials
저자 및
Jason Davis
University of Oxford,
Host Guest and Interlocked Sensors The sensitive and selective detection of anions has much to offer to medical and environmental chemistry. Within this context, the application of surface assembled cationic and hydrogen bond donor molecular systems to electrochemical or optical anion detection (including nanoparticle Plasmon detection) will be discussed. The fabrication of interlocked molecular structures (potential “molecular machines”) as thin films, including the production of rotaxane SAMs on electrodes and nanoparticle surfaces is currently being intensely investigated. To our knowledge however, the application of rotaxane SAMs as charged guest sensing systems has yet to be demonstrated. I will discuss the chloride anion templated surface assembly of a novel redox-active rotaxane where ferrocene redox centres are covalently attached to both the macrocycle wheel and thread axle, and the subsequent changes in electrochemical anion recognition behaviour brought about by interlocking the macrocycle and axle components. Specifically, the geometric confinement imposed on the receptor site by molecular threading greatly enhanced detection specificity. Protein detection and electronics The specific and sensitive detection of protein lies central to advanced in Proteomics and remains challenging. The application of surface immobilised and orientated peptide aptamers in this context will be discussed as will be the uilisation of these detection interfaces in transistor configurations. Catalytic nanolithography The generation of patterned surfaces has attracted considerable attention during the past decade, due to significant and varied potential application in optoelectronics, sensory technology, and the electronics industry. The initiation and control of chemical coupling has the potential to offer much within the context of “bottom up” nanofabrication. In recent work we have reported the use of a palladium-modified, catalytically active, AFM probe to initiate and spatially control surface-confined Suzuki and Heck carbon-carbon coupling reactions. These “chemically written reactions”, detectable by lateral force and chemically specific optical and topographic labeling, were patterned with line widths down to 15 nm or ~20 molecules. Catalyzed organometallic coupling was, in this way, carried out at subzeptomolar levels. By varying the catalyst substrate interaction times, turnover numbers of (0.6-1.2) x 104 and (3.0-5.0) x 104 molecules s-1 were resolved for Suzuki and Heck reactions, respectively.