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  • 09월 05일 13시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Inhibitory effect of SA-252 on RANKL-induced osteoclastogenesis in RAW 264.7 murine macrophage cells

등록일
2007년 8월 9일 14시 53분 25초
접수번호
0231
발표코드
35P272포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅱ>
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
김명희, 김영섭1, 최준식, 민용기2, 김성환3
충남대학교 생화학과,
1한국화학연구원 화학물질연구단,
2한국화학연구원 생명화학연구단,
3한국화학연구원 화학유전체 연구실,
With the fact that the development of anti-resorptive agents from natural substances has gained more interest in the treatment of osteoporosis, here, 222 natural compounds were evaluated whether they have a potential to suppress RANKL-induced osteoclastogenesis in RAW264.7 cells. by using cell-based assay systems in a 384-well plate. Of these compounds, SA-252 significantly inhibited the RANKL-induced TRAP activity and formation of multinucleated osteoclast in a dose-dependent manner. In addition, it was shown to attenuate the RANKL-induced transcript levels of TRAP, matrix metalloproteinase 9 and c-Src, which have been known to be highly expressed in the process of osteoclastogenesis. Interestingly, SA-252 was also shown to inhibit the RANKL-induced activation of mitogen-activated protein kinase and NF-kB signal pathway was inhibited by the treatment of SA-252. In conclusion, it suggested that SA-252 could be useful to develop the therapeutic agents for osteoporosis.

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