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Preparation, analysis and biological activity of detergents based on quaternary heterocycles

등록일
2007년 8월 10일 16시 56분 26초
접수번호
0291
발표코드
35P279포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅱ>
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
Jan Marek, Kamil Musílek, Petr Stodulka, Daniel Jun, Kamil Kuca
Faculty of Military Health Science, University of Defence, Czech Republic,
Detergents based on quaternary nitrogenous heterocycles are already known for many years. Some of them are used as disinfectant or micellar catalysts. In our study, we have focused our attention on the synthesis of three sets of these substances. Pyridinium, quinolinium and isoquinolinium salts differing in the length of the side alkylating chain were synthesized. The length of the alkylating chain was C8-C20. We have also developed the TLC and HPLC method for their identification. Furthermore, we have measured their critical micellar concentrations by spectral method. Then, their ability to inhibit the rat brain cholinesterase was tested. Our future effort will be focused on their antimicrobial activities, because of their similar structure like the benzalkonium salts. The work was supported by the grant of Grant Agency of Ministry of Education, Youth and Sports (Czech Republic) – grant no. ME865.

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