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Versatile Synthesis of Natural Product Analogs in Statin Family

등록일
2007년 8월 10일 17시 28분 07초
접수번호
0296
발표코드
34P180포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅱ>
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
sampath vasu, 이희윤
한국과학기술원 화학과,

In 1975, Endo and co-workers at the Sankyo laboratories isolated an antifungal agent named compactin. Another more active compound mevinolin was later isolated. Due to their biological activity as inhibitors of 3-hydroxy 3-methylglutaryl coenzyme A (HMG CoA) reductase (statins), efforts have been made to discover and synthesize such inhibitors in which the lactone moiety is attached to simpler fragments and such analogs have proven to be more effective than the natural mevinic acids. Herein we describe the synthesis of naturally occurring lactone moiety of stain analogs by the ring opening of epoxide using alkyllithium or lithio-acetylide as the key step in the reaction sequence.


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