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Synthesis of the new group of acetylcholinesterase reactivators with but-2-ene connection chain and oxime group in the position two at the pyridinium ring

등록일
2007년 8월 10일 17시 36분 17초
접수번호
0299
발표코드
35P282포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅱ>
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
Kamil KUCA, Martin PAAR1, Kamil MUSILEK, Daniel JUN, Vladimir CIRKVA2, Jaroslav PEJCHAL, Roman ZMIJA3, Jana KARASOVA, 정영식4
Faculty of Military Health Sciences, University of Defence, Czech Republic,
1Faculty of Pharmacy, Charles University in Prague, Czech Republic,
2Academy of Sciences of the Czech Republic, Institute of Macromolecular Chemistry, Czech Republic,
3Faculty of Sciences, J.E. Purkinje University, Czech Republic,
4한국화학연구원 신약연구단,
Acetylcholinesterase reactivators are drugs generally used as antidotes in the case of pesticide and nerve agent poisoning. Design and synthesis of these compounds is the main aim of our department. We have developed more than three hundred different compounds within last five years. In this presentation, new group of our bisquaternary reactivators (but-2-ene connection chain and oxime group in the position two at the pyridinium ring) together with their biological activity will be shown. All these reactivators were derived from the oxime BI-6 (Czech origin) – promising reactivator against cyclosarin. The work was supported by the grant of Grant Agency of Ministry of Education, Youth and Sports (Czech Republic) – grant no. ME865.

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