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129th General Meeting of Korean Chemical Society & Exposition Photosensitizer-peptoid conjugates: multitargeting antimicrobial photodynamic therapy agent

Submission Date :
2 / 28 / 2022 , 09 : 38 : 02
Abstract Number :
129022826148
Presenting Type:
Poster Presentation
Presenting Area :
Life Chemistry
Authors :
Jiwon Seo*, Woojin Yang
Department of Chemistry, Gwangju Institute of Science and Technology, Korea
Assigned Code :
LIFE.P-363 Assigend Code Guideline
Presenting Time :
April 15 (FRI) 11:00~13:00

Multitarget antimicrobials have shown promising activity because they minimize the resistant development of bacteria, and are thus considered in the clinic. Here, we prepared the conjugates of antimicrobial peptoids and photosensitizers that show multitargeting antimicrobial activity. A library of photosensitizer-peptoid conjugates (PsPCs) was synthesized using solid-phase methods, and the structure-activity relationship was studied by employing different peptoid structures, linkers, and photosensitizers. PsPC 9 exhibited the most promising photoresponsive activity among the synthesized PsPCs, which consists of weakly helical peptoids, glycine linkers, and positively charged porphyrins. It was confirmed by spectroscopic analyses that the singlet oxygen was generated upon the excitation of PsPC 9 with blue light. Further studies with flow cytometry and DNA gel electrophoresis demonstrated that PsPC 9 could damage the bacterial membrane and plasmid DNA of gram-negative bacteria. The promising photoresponsive activity of PsPC 9 suggests that an optimal combination of peptoids and photosensitizers provides an efficient antimicrobial photodynamic therapy agent with a multitargeting strategy.