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  • 09월 05일 13시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Structure-activity relationship of acetylcholinesterase reactivators – antidotes against nerve agents

등록일
2007년 8월 13일 10시 24분 10초
접수번호
0386
발표코드
35P283포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅱ>
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
Kamil KUCA, Kamil MUSILEK, Daniel JUN, Jan MAREK, Miroslav POHANKA1, Vlastimil DOHNAL, Jiri BINDER2, Lucie MUSILOVA2
Faculty of Military Health Sciences, University of Defence, Czech Republic,
1Central Military Institute of Health, Czech Republic,
2Faculty of Pharmacy, Charles University in Prague, Czech Republic,
Development of new acetylcholinesterase (AChE) reactivators is a very important task at present time due to the possibile misuse of the nerve agents by terrorist groups. AChE reactivators differ in the structure mainly in a position of the oxime group, in number of quaternary nitrogens presented in the molecule and in a length and shape of the linker connecting two heteroarenium rings. In this study, the structural requirements, which should be considered for further design of these compounds, will be shown. The work was supported by the grant of Grant Agency of the Czech Republic – grant no. 305/07/P162.

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