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129th General Meeting of Korean Chemical Society & Exposition Investigation of multiple strategies for mass spectrometry based proteomic analysis of bronchoalveolar lavage fluid from lung cancer patients

Submission Date :
2 / 28 / 2022 , 14 : 09 : 22
Abstract Number :
129022826977
Presenting Type:
Oral Presentation
Presenting Area :
Analytical Chemistry - Oral Presentation of Young Analytical Chemists I
Authors :
Minh Hung Vu, Min-Sik Kim*
Department of New Biology, DGIST, Korea
Assigned Code :
ANAL1.O-7 Assigend Code Guideline
Presenting Time :
THU, 09 : 24
Mass spectrometry analysis is a prominent technique for clinical proteomics. Several strategies have been developed to advance biomarker identification from liquid biopsies. Bronchoalveolar lavage fluid (BALF) has recently emerged as a promising source of protein biomarkers for lung cancer. However, challenges due to the properties of BALF have limited the sensitivity and specificity of mass spectrometry-based biomarker identification. Therefore, we systemically investigated different approaches, including sample preparation, peptide fractionation, and data acquisition for quantitative proteomic analysis of BALF from lung cancer patients. Herein, we will address the advantages and caveats of each strategy and propose a potential procedure for biomarker identification from clinical samples.