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129th General Meeting of Korean Chemical Society & Exposition Point-of-care-test method for measurement of hydrogen sulfide level in blood

Submission Date :
2 / 28 / 2022 , 16 : 12 : 57
Abstract Number :
Presenting Type:
Oral Presentation
Presenting Area :
Life Chemistry - Oral Presentation for Young Scientists in Biochemistry and Chemical Biology
Authors :
Yecheol Bak, Sehoon Kim1,*
Center for theragnosis, Korea Institute of Science and Technology/Program in Applied Bioengineering, Korea
1Center for theragnosis, Korea Institute of Science and Technology, Korea
Assigned Code :
LIFE.O-7 Assigend Code Guideline
Presenting Time :
THU, 10 : 12
Hydrogen sulfide (H2S) is a 3rd gas transmitter that plays a role as an antioxidant and cell-signaling molecule in the body. Numerous researchers have been reported a decrease of H2S level has been linked to several diseases such as Alzheimer’s disease, hypertension, and diabetes. Traditional methods like HPLC, gas chromatography, and colorimetric-based assay have been used to detect H2S. However, these methods required high-cost equipment and a complex pre-treatment process which is hard to adapt in POCT. In our case, we have developed a protein-free one-step method that is practical for applying to a portable POCT method and highly selective metal complex toward H2S using the electrochemiluminescence (ECL) technique. Without any further pretreatment, we have successfully been measured a difference between the disease group and control group’s H2S blood level in an animal model.