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129th General Meeting of Korean Chemical Society & Exposition Copper-Catalyzed Asymmetric Borylative Coupling of Terminal Enynes with Conjugated Diesters

Submission Date :
2 / 28 / 2022 , 15 : 24 : 57
Abstract Number :
129022827498
Presenting Type:
Poster Presentation
Presenting Area :
Organic Chemistry
Authors :
Wan seok Yoon, Jaesook Yun*
Department of Chemistry, Sungkyunkwan University, Korea
Assigned Code :
ORGN.P-620 Assigend Code Guideline
Presenting Time :
April 15 (FRI) 11:00~13:00

We recently reported copper-catalyzed conjugative addition of alkylcopper nucleophiles to Michael acceptors, resulting in enantioselective formation of C(sp3)–C(sp3) bond with a single stereocenter. However, further attempts to increase the steric bulk of the alkylcopper-nucleophile derivatives from primary to secondary were not successful. Herein, we successfully developed an efficient asymmetric catalytic methods that employ two prochiral alkenes to form C(sp3)–C(sp3) bond with concomitant stereocontrol. In this work, we obtained the coupled product of 1,3-enynes and α,β-unsaturated diesters with high diastereo- and enantioselectivity.