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129th General Meeting of Korean Chemical Society & Exposition Molecular swarm agents for massively parallel inspection and reconstruction of molecular landscapes

Submission Date :
2 / 28 / 2022 , 15 : 51 : 27
Abstract Number :
129022827666
Presenting Type:
Symposium
Presenting Area :
Inorganic Chemistry - A New Horizon in Inorganic Chemistry
Authors :
Sungwook Woo
Department of Chemistry, Pohang University of Science and Technology, Korea
Assigned Code :
INOR1-5 Assigend Code Guideline
Presenting Time :
THU, 17 : 20
Current methods of studying molecular systems are often limited in throughput, because they either treat all molecules equally (as in ensemble measurements) or examine one molecule at a time (as in single-molecule measurements). In this talk, an approach based on molecular swarm agents for surveying molecular landscapes will be presented. Molecular swarm agents are DNA-based motors that can copy information from targets and generate records that reflect the trajectory. A swarm of agents can roam around and record spatial organizations of molecular systems and their conditional changes in a massively parallel manner, with each agent reporting information on local arrangements and collectively allowing us to reconstruct the global map. Data will be presented demonstrating the basic mechanisms and a few model systems where the agents were used to count the number of subunits in molecular complexes or to detect the state changes in molecular arrangements. This technology will enable new capabilities in fundamental molecular sciences by providing an unprecedented tool for parallel and multiplexed examination of molecular systems.