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129th General Meeting of Korean Chemical Society & Exposition Covalent Writing of Single DNA Molecules using AFM

Submission Date :
2 / 28 / 2022 , 16 : 09 : 03
Abstract Number :
Presenting Type:
Poster Presentation
Presenting Area :
Life Chemistry
Authors :
Eung-Sam Kim
Department of Biological Sciences, Research Center of Ecomimetics and Center for Next Generation Sensor Research and Development, Chonnam National University, Korea
Assigned Code :
LIFE.P-366 Assigend Code Guideline
Presenting Time :
April 15 (FRI) 11:00~13:00
In contrast to the conventional top-down microfabrication, bottom-up micropatterning or nanopatterning can be viewed as the localization of target molecules to the desired position of a two-dimensional surface. These processes rely on the physical adsorption of ink-like molecules to the paper-like surface, resulting in unstable immobilization of the target molecules through their noncovalent linkage to the surface. Herein, successive single DNA nick-sealing on a dendron-coated silicon surface allowed us to covalently immobilize individual DNA molecules at defined positions via atomic force microscopy. The covalently-patterned ssDNA that was biotinylated at its terminal was visualized by streptavidin-coated gold nanoparticles. The successive covalent positioning of the target DNA under ambient conditions may facilitate the bottom-up construction of DNA-based nanostructures, nanorobots, or data storage.