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129th General Meeting of Korean Chemical Society & Exposition Conformational analysis of β-peptides containing trans-4,4-dimethyl-2-aminocyclopentanecarboxylic acid (trans-dmACPC)

Submission Date :
2 / 28 / 2022 , 16 : 55 : 23
Abstract Number :
129022828788
Presenting Type:
Poster Presentation
Presenting Area :
Organic Chemistry
Authors :
Heewon Choi, Soo Hyuk Choi1,*
chemistry, Yonsei University, Korea
1Department of Chemistry, Yonsei University, Korea
Assigned Code :
ORGN.P-638 Assigend Code Guideline
Presenting Time :
April 15 (FRI) 11:00~13:00
Peptide foldamers can display a specific secondary structure by different hydrogen bonding patterns. It is well known that trans-2-aminocyclopentanecarboxylic acid (trans-ACPC) oligomers adopt 12-helical conformations. By replacing trans-ACPC with transs-dmACPC, an unusual secondary structure can be formed. A previous work suggests that oligomers of trans-dmACPC and trans-ACPC show distinctive nuclear Overhauser effects (NOEs) that implies 16-helix structure. Our group synthesized oligomers that consist of trans-ACPC and trans-dmACPC. Conformational analysis was conducted through Circular Dichroism and NMR methods.