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129th General Meeting of Korean Chemical Society & Exposition Anlysis of reactive chemical species and its metabolite in animal modell by immuno assay and electrochemiluminescence.

Submission Date :
2 / 28 / 2022 , 16 : 54 : 51
Abstract Number :
129022828848
Presenting Type:
Poster Presentation
Presenting Area :
Life Chemistry
Authors :
Ji hwan Park, Yecheol Park1, Sehoon Kim1,*
Medical Convergence Engineering, KU-KIST Graduate School of Converging Science and Technology, Korea
1Korea Institute of Science and Technology, Korea
Assigned Code :
LIFE.P-370 Assigend Code Guideline
Presenting Time :
April 15 (FRI) 11:00~13:00
Recently, numerous studies revealed the correlation between reactive chemical species (RCS), its metabolites, and diverse diseases such as diabetes, Alzheimer's, or atherosclerosis. It indicates that RCS and its metabolites play a role as important candidates for biomarkers that can be used for the pre-diagnosis of fatal diseases. However, short lifetime, small size, and various interactions with protein interfere with RCS and the detection of its metabolites in the blood. To verify the level of RCS and its metabolite in blood, we constructed a coronary artery disease, hyperlipidemia, diabetes mellitus model and conducted an enzyme-linked immunosorbent assay (ELISA). Finally, we successfully selected the most disease-relevant essential analyte, and develop the immuno-electrochemiluminescence(immuno-ECL) system for sensitive detection of the analyte in blood