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129th General Meeting of Korean Chemical Society & Exposition Quantitation and Speciation of Inorganic Arsenic in a biological sample by Capillary Ion Chromatography coupled with Inductively Coupled Plasma Mass Spectrometry

Submission Date :
2 / 28 / 2022 , 19 : 34 : 29
Abstract Number :
129022828978
Presenting Type:
Poster Presentation
Presenting Area :
Analytical Chemistry
Authors :
Seon-jin Yang, Sang-Ho Nam*, Yonghoon Lee
Department of Chemistry, Mokpo National University, Korea
Assigned Code :
ANAL.P-345 Assigend Code Guideline
Presenting Time :
April 14 (THU) 11:00~13:00
Arsenic is a nonmetallic element known to be toxic to the human body, and when it accumulates in our bodies through food and drinking water can cause serious illness. Since arsenic has different toxicity depending on its chemical form, it is important to measure not only the element itself but also the arsenic species. For the separation of arsenic species, cation and anion exchange separation columns are used, where the sample loop volume used is usually 100-200 μL. However, the amount of sample actually required is at least 0.5 to 1 mL or more. In this case, it is difficult to apply to limited samples such as clinical and biological samples. Therefore, in this study, a method for separating arsenic species was developed by using a capillary ion exchange column with a sample loop of 5 μL to reduce the sample volume. The separated arsenic was measured by inductively coupled plasma mass spectrometry (ICP-MS). For inorganic arsenic, a linear calibration curve from 0.5 μg/kg to 25 μg/kg was obtained, and the correlation coefficient was 0.9999. Using the developed method, the rate of recovery of inorganic arsenic from standard certified substances in water was about 100%, and the rate of recovery of inorganic arsenic from urine standard certified substances with complex substrates was about 121%.