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129th General Meeting of Korean Chemical Society & Exposition Back-scattering based axially slanted laser illumination scheme for direct composition analysis of sample housed in a glass container

Submission Date :
2 / 17 / 2022 , 14 : 02 : 35
Abstract Number :
Presenting Type:
Poster Presentation Analytical Chemistry Oral Presentation
Presenting Area :
Analytical Chemistry
Authors :
Haeseong Jeong, Sang Hoon Cho, Hoeil Chung1,*, Daun Seol2
chemistry, Hanyang University, Korea
1Department of Chemistry, Hanyang University, Korea
2Research Institute for Convergence of Basic Science, Hanyang University, Korea
Assigned Code :
ANAL.P-355 Assigend Code Guideline
Presenting Time :
April 14 (THU) 11:00~13:00
An axially slanted illumination (ASI) scheme slantingly irradiating laser on the headspace side of a glass container and positioning a detector beneath the container was previously demonstrated to determine gemcitabine concentration (42.9-58.2 wt%) in the gemcitabine injection powder housed in a glass container. Using the ASI scheme, the spectral features of the gemcitabine powder became distinct with only a weak underlying glass background signal. Meanwhile, since the distance between the laser illumination spot and detector location was increased in the ASI scheme, the attenuation of Raman signal was inevitably large. So, it would not adequate to determine concentration of low-level active pharmaceutical ingredient (API) in a housed pharmaceutical sample due to the degraded signal-to-noise ratio. To secure the enhanced signal-to-noise ratio of API peak, a conventional back-scattering (BC) measurement is preferred; however, the strong presence of glass background is problematic. To increase the intensity of API peak with diminished glass background, BC based ASI (BC-ASI) scheme was explored in this study. The BC-ASI scheme tried to incorporate the advantages of both BC and ASI measurements together in one configuration. Use the BC-ASI scheme, pharmaceutical samples (API concentration below 5.0wt%) housed in a glass vial were measured and subsequent accuracy of API concentration determination was compared with those of BC and ASI measurements.