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  • 09월 05일 13시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

PDE-4 Inhibitors; Efficacy or Side Effect?

등록일
2007년 8월 13일 16시 56분 31초
접수번호
0468
발표코드
목20G1심 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 14시 : 00분
발표형식
심포지엄
발표분야
의약화학 - Recent Overview for Overcoming Immune and Inflammatory Diseases
저자 및
공동저자
노재성
한국파스퇴르연구소 의약화학연구그룹,
The potential use of PDE-4 inhibitors as anti-inflammatory agents for the treatment of inflammatory lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) has received much attention from the pharmaceutical sector since the end of 1990s’. However, A representative PDE-4 inhibitor, roflumilastTM, suffered from dose limiting side effects including nausea and emesis and/or low clinical efficacy which restricted their therapeutic use. Therefore, to implement PDE-4 for anti-asthma and/or anti-COPD, it is still necessary to know the origins of low efficacies and side effects (mechanism-based or chemical-based?). As part of our program to develop novel anti-inflammatory chemical entities, we present here our struggle for the development of novel PDE-4 inhibitor scaffolds with little side effects.

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