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Design and Synthesis of TriazoleGlycolipids for CD1d-Mediated NKT Cell Activation

등록일
2007년 8월 16일 17시 25분 14초
접수번호
1196
발표코드
목20G2심 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 14시 : 30분
발표형식
심포지엄
발표분야
의약화학 - Recent Overview for Overcoming Immune and Inflammatory Diseases
저자 및
공동저자
김상희
서울대학교 약학대학,
The first defined and most potent agonistic antigen of the TCR of NKT cells is α-GalCer. We found that the bioisosteric replacement of α-GalCer’s amide moiety with triazole increases the IL-4 vs IFN-γ bias of released cytokines. In particular, the long-chained triazole analogues have a comparable stimulatory effect on cytokine production as α-GalCer, and exhibit a stronger Th2 cytokine response. Our modeling studies implied that the slightly altered topological features and hydrogen bonding patterns might influence the cytokine release profile, possibly through alteration of the interaction between TCR and CD1d. Since IL-4 is a key cytokine for the control of autoimmune diseases such as type 1 diabetes and multiple sclerosis, the triazole analogues might be more useful than α-GalCer for the treatment of these diseases.

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