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Design and Synthesis of Modified Grubbs Catalyst for Ring Closing Metathesis

등록일
2007년 8월 20일 14시 54분 49초
접수번호
1324
발표코드
34P256포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅳ>
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
황원미, 김세영, 임인선, 이상기1, 김병문
서울대학교 화학부,
1이화여자대학교 나노과학부,
Ring-closing metathesis has become one of the most powerful and versatile methods in organic chemistry for the synthesis of cyclic structures mainly because of the development of ready-to-use ruthenium precatalysts. Grubbs-Hoveyda catalyst is found to be tolerant of a wide variety of functional groups, highly reactive and recyclable, however it has a relatively slow initiation rate. To improve the reactivity of the catalyst, we designed and synthesized novel carbene compounds which possess nitrogen-containing heterocycles such as imidazole and pyridine. The modified catalysts were transformed into various ammonium salts upon treatment with a range of acids and then subjected to RCM reactions. Some of the acid complexes showed considerable enhancement of reactivity for RCM, accelerating the reaction several fold. This novel catalyst proved to be quite stable to air and was easily recovered from column chromatography.

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