Organosulfure compounds are valuable because of their rich and varied chemistry especially in the field of biological chemistry. Lawesson's reagent and combination of P4S10 and hexamethyldisiloxane are commonly used for combination of amide to thioamide. However, theses reagents are expensive or not easy to handle.
We report a new efficient way to convert amide to thioamide using P4S10 and silicon oil tandem. These reagents are easy to handle and recyclable.