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  • 09월 05일 13시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Electrogenerated Chemiluminescence Using Ru(bpy)32+-doped Silica Nanoparticles for Protein-Protein Interactions

등록일
2007년 9월 4일 14시 20분 43초
접수번호
1599
발표코드
금23J2심 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 10시 : 00분
발표형식
심포지엄
발표분야
전기화학 - Q Won Choi Award Memorial Symposium
저자 및
공동저자
김하석, 김양래
서울대학교 화학부,

Silica nanoparticles containing luminophors were utilized for quantitative information of protein. They were used for mass changes by quartz crystal microbalance and light intensity by electrogenerated chemiluminescence based on protein-protein interaction after proper surface modifications. Uniform-size Ru(bpy)32+-doped silica nanoparticles were prepared by water in oil microemulsion method and characterized by electrochemical method, photobleaching, and transmission electron microscopy (TEM). A sandwich type immunoassay system with the labeling of a luminophore, tris(2,2'-bipyridyl)- ruthenium(II), in the second antibody was demonstarted. (Fig. 1) For this purpose, Ru(bpy)32+-doped silica nanoparticles were synthesized and the particle size of the particle were controlled by various combinations of precursor. Details of interaction between IgG and anti-IgG and ECL efficiency for protein quantification will be discussed.


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