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  • 02월 22일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Regioselective synthesis of poly-substituted 2-hydroxypyridines from Baylis-Hillman adducts via consecutive [3+2+1] annulation protocol

등록일
2008년 2월 4일 14시 35분 55초
접수번호
0059
발표코드
32P78포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅱ>
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
김성환, 김세희, 김재녕
전남대학교 화학과,

Recently we developed an efficient synthetic procedure for poly-substituted pyridine derivatives via [3+2+1] annulation protocol. The compounds were prepared starting from the Baylis-Hillman adducts of alkyl vinyl ketones via the sequential introduction of active methylene compounds and the following reaction with NH4OAc in acetic acid medium. As an extension in this poster we describe on the synthesis of poly-substituted 2-hydroxypyridine 3a by using the same concept starting from the Baylis-Hillman adducts of methyl acrylate. Introduction of active methylene compounds was carried out similarly as before to prepare 1a, however, the next cyclization of 1a to 3a could be effected under the influence of large excess amounts of NH4OAc (20 equiv) as in the following Scheme.


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