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  • 02월 22일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Pd-mediated synthesis of poly-fused heterocyclic compounds from Baylis-Hillman adducts modified with isatin, imidazole, and benzimidazole moieties

등록일
2008년 2월 4일 14시 37분 37초
접수번호
0066
발표코드
32P85포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅱ>
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
이현승, 김고훈, 김재녕
전남대학교 화학과,

Recently we reported the synthesis of 7H-benzo[3,4]azepino[1,2-a]indole-6-carboxylic acid derivatives from the Pd-mediated intramolecular cyclization reaction of indole-attached Baylis-Hillman adducts. Depending upon the substitution pattern at the 2-position of indole moiety, seven- and eight-membered ring compounds were formed selectively. As an extension in this poster we describe on the results for the Pd-mediated cyclization reactions of isatin-attached and benzimidazole-attached Baylis-Hillman adducts. The starting materials were synthesized by the reaction of Baylis-Hillman acetate and isatin (or benzimidazole) in the presence of KOH. From these substrates we obtained eight- and seven-membered cyclic compounds as shown below, although the yields were lower than the previous indole cases.


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