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초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

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  • 01월 01일 09시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Structural Genomics of Cellular Signaling: Human Protein Tyrosine Phosphatases

등록일
2005년 2월 17일 10시 46분 04초
접수번호
0808
발표코드
금9E4심 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 15시 : 25분
발표형식
심포지엄
발표분야
생명화학 - 생명Ⅰ: 신호전달과 분자 스위치
저자 및
공동저자
김승준
한국생명공학연구원 단백질체시스템,
One of the major regulatory mechanisms in signal transduction pathway includes the phosphorylation/dephosphorylation on tyrosine residues where protein tyrosine phosphates (PTP) play a role in controlling the signal within cell. Members of superfamily of PTPs can be classified into three sub-type (classical, dual-specific, low-molecular weight PTPs). Currently, 90-100 members of PTPs are identified as unique human PTPs and many PTPs are implicated as promising drug target for diverse diseases. Our research goal is focused on the understanding of the individual function and structure of PTPs by determining three dimensional structures of PTPs. During the last two years, the efforts to define non-redundant PTP catalytic domain, make optimal constructs for soluble proteins, extensively purify and crystallize led to ten diffractable crystals. Currently, we have determined newly eight members of PTP structures, which are corresponding to ~40% of known human PTP structures, so far. The elucidation of structure of PTPs will trigger rapid development of specific inhibitors that are developed for the clinic later. I will also briefly introduce our project of the discovery of anti-cancer drugs targeting PRL phosphatases.

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