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  • 03월 04일 13시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Microwave-Assisted Synthesis of Mebrofenin

등록일
2005년 2월 17일 13시 02분 56초
접수번호
0863
발표코드
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발표시간
금 <발표Ⅰ>
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
박상현, 권희정, 장승호, 박응우, 신병철, 박경배
한국원자력연구소 동위원소이용연구부,
99mTc-Labeled N-(3-bromo-2,4,6-trimethylacetanilido)iminodiacetic acid (99mTc-mebrofenin) has been used to assess the functional integrity of the hepatobiliary system. A fast and convenient procedure was established for the synthesis of mebrofenin and radiochemical labeling with 99mTc. 3-Bromo-2,4,6-trimethylacetanilide was synthesized in large scale under microwave irradiation (300 W, 5 min) by acylation (60% yield) and bromination (96% yield). And it was treated with the disodium salt of iminodiacetic acid under microwave irradiation (300 W, 20 min) to afford mebrofenin in 86% yield. The attractive feature in this procedure involves microwave irradiation which results in shorter reaction times, higher yields, cleaner reaction products and an easier work-up than classical heating. The synthesis time of 2,4,6-trimethylacetanilide is reduced from 1 hr to 5 min; the synthesis time of 3-bromo-2,4,6-trimethylacetanilide is reduced from 24 hr to 5 min; the synthesis time of mebrofenin is reduced from 48 hs to 20 min, when compared with that of the conventional method.

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