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  • 03월 04일 13시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Novel and Efficient Preparation of 188Re (I) Tricarbonyl Precursor, [188Re(OH2)3(CO)3]+ for the Labeling of Biomolecules

등록일
2005년 2월 17일 13시 11분 16초
접수번호
0871
발표코드
25P263포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
토 <발표Ⅲ>
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
박상현, 장승호, 권희정, 한광희, 박경배
한국원자력연구소 동위원소이용연구부,
The 99mTc(I) and 188Re(I) tricarbonyl precursors [M(OH2)3(CO)3]+ have been shown to be excellent starting materials for the synthesis of [99mTc(I) and 188Re(I) tricarbonyl complexes as well as radiolabelling of target specific biomolecules. A novel and efficient preparation of 188Re (I) tricarbonyl precursor, [99mRe(OH2)3(CO)3]+ for the labeling of biomolecules was established. The recently described borohydride exchange resin (BER) as an additional reducing agent to improve the labeling yields. Optimal yields of the precursor complex were obtained using the following preparation conditions: To a vial containing a mixture of 3 mg K2[BH3CO2], 3 mg BH3NH3, and 3 mg BER, 1.0 ml of [188Re]perrhenate eluate and 8 µl phosphoric acid (85 %) were added. The vial was incubated at 60 ℃ for 15 min. Pressure from the evolving H2 gas was balanced with a 20 ml syringe. 90-95 % of the desired 188Re(OH2)3(CO)3]+ complex were found by HPLC and TLC analyses. The identity of the precursor was confirmed by reaction with histidine.

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