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  • 02월 22일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Direct evidence for and iron(IV)-oxo porphyrin π-cation radical as an active oxidant in catalytic oxygenation reactions

등록일
2008년 2월 13일 17시 26분 29초
접수번호
1156
발표코드
28P150포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅳ>
발표형식
포스터
발표분야
무기화학
저자 및
공동저자
강예은, 정유진, 남원우1
이화여자대학교 나노과학부,
1이화여자대학교 화학과,
Elucidation of the nature of reactive intermediates in the catalytic cycle of dioxygen activation and oxygen atom transfer reactions by Cytochromes P450 (CYP 450) has been a subject of intense research in the bioinorganic and biological chemistry communities. It has been believed for a long time that high-valent iron(IV)-oxo porphyrin π-cation radicals, so called Compound I (Cpd I), are generated via O-O bond heterolysis of ferric-hydroperoxo porphyrins, so called Compound 0 (Cpd 0), and are the active oxidants that effect the oxygenation of organic substrates. Although Cpd I has been poorly characterized in enzymatic reactions, probably due to a high reactivity and instability in nature, a number of synthetic iron(IV)-oxo porphyrin π-cation radicals have been prepared and investigated in various oxygenation reactions, including alkane hydroxylation and olefin epoxidation. Thus, there is no doubt that Cpd I is a strong oxidant capable of oxygenating various organic substrates.

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