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  • 02월 22일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Effect of Ionic Strength on RNA-binding Protein Complex Conformation – A Molecular Dynamics Simulation Approach

등록일
2008년 2월 14일 10시 24분 16초
접수번호
1254
발표코드
31P56포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅱ>
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
Prettina Lazar, 이근우1
경상대학교 응용생명과학부,
1경상대학교 생화학과 응용생명과학부 EB-NCRC,
Behavior of peptide/protien in saline aqueous solution is a fundamental topic in physical chemistry.The influence of salt on the conformation and physical properties of biomolecules in solution is an essential factor and very little is known about the stabilizing/destabilizing interactions which are important in explaining the observed effects. To investigate the effects of added salts on protein conformation and dynamics, we used molecular dynamics (MD) to stimulate Staphylococcus aureus Hfq protein under two different ionic concentrations: 0.1M and 1.0M, with and without RNA and explicit TIP3P water molecule using AMBER forcefield for 3ns. Essential Dynamics analysis was also carried out to gain insights into the dynamic properties of ionic salt concentration on the stability of RNA-protein complex. We were particularly interested in any ion induced conformational changes and strong correlations between the ions and the ionic moieties on the protein.

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