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  • 08월 28일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Synthesis and Biological activities of New Fluoroarylformamidine Derivatives Possessing N'-(dialkylamino)sulfenyl Subgroup

등록일
2008년 7월 30일 15시 18분 35초
접수번호
0013
발표코드
34P188포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅱ>
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
이동국, 고영관, 류재욱, 우재춘, 구동완, 정근회
한국화학연구원 항암제연구센터, Korea

Phenylformamidine derivatives are well known as miticides for their specific activity against many kind of mites in the all life cycle stages: egg (hatching inhibition), nymph (mortality), female adult (inhibit oviposition) and male adults (sterility). It has been established that they show insecticidal activity as agonists on the octopamine receptor which is located in the synapse membrane. In order to get a highly active compound we have intensively exploited fluoro-substituted phenylformamidine derivatives. Up to now, there are several candidates we found: N'-(di-n-butylamino)sulfenyl-N‘-methyl-N-(4-fluoro-2-methylphenyl)formamidines. The miticidal activity of those compounds show five-fold higher than Amitraz. We report here the synthesis of new compounds and their biological activities.


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