Phenylformamidine derivatives are well known as miticides for their specific activity against many kind of mites in the all life cycle stages: egg (hatching inhibition), nymph (mortality), female adult (inhibit oviposition) and male adults (sterility). It has been established that they show insecticidal activity as agonists on the octopamine receptor which is located in the synapse membrane.
In order to get a highly active compound we have intensively exploited fluoro-substituted phenylformamidine derivatives. Up to now, there are several candidates we found: N'-(di-n-butylamino)sulfenyl-N‘-methyl-N-(4-fluoro-2-methylphenyl)formamidines. The miticidal activity of those compounds show five-fold higher than Amitraz.
We report here the synthesis of new compounds and their biological activities.