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  • 08월 28일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Single Cell Detection based on Intermolecular Double Quantum Coherence

등록일
2008년 7월 30일 16시 02분 48초
접수번호
0017
발표코드
33P164포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅰ>
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
조지현, 이철현, 안상두1
한국기초과학지원연구원 MRI팀, Korea
1중앙대학교 화학과, Korea
Most imaging studies using intermolecular multiple quantum coherences (iMQCs) have focused on the two-spin dipolar interactions – zero and double quantum coherences [1]. First we report the experimental results to assess the feasibility of magnetic resonance microscopy with intermolecular double quantum coherence (iDQC) in a model system at 14 T. The results demonstrates that the iDQC microscopic images are readily observable at high field, and have unique contrast depending on the sample micro-structure and coherence order. And we applied this method to in vitro model cell system [2]. Here we show intermolecular double quantum coherence (iDQC) and gradient echo (GE) images of the iron-labeled macrophage cells in agar gel. We obtained the iDQC and GE images at various spatial resolutions and different slice thickness conditions. These results show that iDQC images show more effectively the labeled cells with high CNR than conventional GE images especially at the lower spatial resolution and thicker slice thickness. From these results we think that iDQC imaging can be alternative to the conventional GE imaging for the labeled cell detection and stem cell tracking, and for the application to the small tumor detection.

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