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  • 08월 28일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Palladium-Catalyzed C-H Functionalization of Pyridine N-Oxides: Highly Selective Alkenylation and Direct Arylation with Unactivated Arenes

등록일
2008년 8월 5일 13시 29분 04초
접수번호
0136
발표코드
금34A8구 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 11시 : 30분
발표형식
구두발표
발표분야
유기화학
저자 및
공동저자
조승환, 황승준, 장석복
한국과학기술원 화학과, Korea

Transition metal-catalyzed C-H bond functionalization for the C-C bond formation has emerged as a promising area in organic synthesis. In particular, reactions involving Pd-catalyzed activation of sp2 or sp3 C-H bonds of arenes or alkanes have been extensively investigated. Successful applications of the similar activation strategy on readily available substrates have been also reported using various metals other than Pd catalysts. In light of the importance of C-H bond transformation, we have developed two catalytic protocols of the oxidative C-C bond formation on the basis of the C-H bond activation of pyridine N-oxides. Pd-Catalyzed alkenylation of the N-oxides proceeds with excellent regio-, stereo-, and chemoselectivity, and the corresponding ortho-alkenylated N-oxide derivatives are obtained in good to excellent yields. Direct cross-coupling reaction of pyridine N-oxides with unactivated arene was also developed in the presence of Pd catalyst and Ag oxidant, which affords ortho-arylated pyridine N-oxide products with high site-selectivity.


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