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  • 08월 28일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Screening and identification of TRAIL-induced apoptosis modulator : TM 2

등록일
2008년 8월 9일 17시 42분 06초
접수번호
0422
발표코드
33P177포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅰ>
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
황미경, 민용기, 김성환
한국화학연구원 신약기반기술센터 화학유전체 연구실, Korea
We screened and identified TRAIL-induced apoptosis modulator, TM2. In this study, we have examined the molecular events induced by TM2 and explored possible mechanisms of TM2- induced apoptosis. We found that small-molecule TM2 arrested mitotic G2 phase in cell cycle and rapid caspase 8 activation in human lung cancer cells. And we showed that the apoptosis-inducing activity of TRAIL can be enhanced by TM2 combined with recombinant TRAIL. TM2 down regulated the expression of Bcl-2, XIAP and Survivin and inhibited phosphorylation of ERK. Treatment with TM2 sensitized the cells to TRAIL-induced cell death, following exit from mitosis. Thus, TM2–induced apoptosis might offered another mechanism to enhance activation of the death receptor pathway

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