abs

학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 08월 28일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Synthesis of Di-spirohydantoins with potassium cyanide and ammonium carbonate

등록일
2008년 8월 11일 15시 23분 06초
접수번호
0602
발표코드
34P176포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅲ>
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
박혜란, 이언진, 정대일1, 한정태2
동아대학교 화학과, Korea
1Department of chemistry lowa state university, U.S.A, United States
2영동대학교 뷰티케어과, Korea
A series of tropane and nortropane 3-spiro-5’-hydantoins showed anticonvulsant activity against pentylenetetrazol-induced convulsions in mice and antiarrhythmic activity in rabbit previously treated with ouabain. We already reported the synthesis of N-substituted 8-aza-bicyclo[3,2,1]octan-3-ones derived from the reaction of amine, 2,5-dimethoxytetrahydrofuran and acetonedicarboxylic acid. And also we reported the synthesis of di-(8-azabicyclo[3,2,1]octan-3-only)-benzenes and di-(8-azabicyclo[3,2,1]-octan-3-only)alkanes in the reaction of phenylenediamines (or diaminoalkanes) with 2,5-dimethoxytetrahydrofuran, and acetonedicarboxylic acid. As a part of our study on the improvement of anticonvulsant, we report the synthesis of corresponding novel spirohydantoin derivatives by using N-substituted 8-azabicyclo[3,2,1]octan-3-ones and di-(8-azabicyclo [3,2,1]octan-3-only)benzenes(or alkanes) with potassium cyanide and ammonium carbonate.

상단으로