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  • 08월 28일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Organocatalytic Highly Enantioselective Radical Addition Reactions

등록일
2008년 8월 11일 15시 26분 54초
접수번호
0609
발표코드
34P179포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅲ>
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
김상윤, 장두옥
연세대학교 화학과, Korea

Recent investigations have shown that the stereochemistry of radical reactions could be controlled without using chiral auxiliaries. The development was achieved mainly in the radical conjugate addition promoted by chiral Lewis acids, which formed the chiral environment by coordinating the substrates. However, there have been no reports on asymmetry induction in radical reactions through a π-stacking and/or hydrogen bonding chiral environment. We herein report on the development of an enantioselective radical addition reaction to acylhydrazones for preparing enantioenriched amines with ammonium salts of cinchona alkaloid derivatives. The addition reactions of alkyl halides to various acylhydrazones of aldehydes were performed, affording addition adducts in high chemical yields with high enantioselectivities.


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