abs

학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 08월 28일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

CMBP Meditated Mitsunobu reaction of N-sulfonamide protected amino alcohol derivatives

등록일
2008년 8월 11일 15시 54분 06초
접수번호
0624
발표코드
34P181포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅲ>
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
김지연, 전근호1, 남정이1
숭실대학교 화학과, Korea
1숭실대학교 기초과학부, Korea
CMBP (Cyanomethlyene tri-n-butyl phosphorane) was introduced for the Mitsunobu reaction between alcohol and acid which has a pKa higher than 11. As a result, CMBP has showed enhanced reactivities and sucessfully overcome the pKa limitation of the Mitsunobu reaction. When we tried to prepare aziridine derivatives from N-sulfonamide protected amino alcohols by treating CMBP, unexpected CH2CN added products were produced. Normal alcohols (without amino group) have reported not to prepare such an addition product. We suspected that the addition product should be synthesized via the ring opening of an aziridine intermediate. For detailed inverstigations of reactivity and mechanism in the formation of the unusual addition product, various sulfonamides including Ns, Ms, Ts and Bts protected amino alcohols were prepared and their reactions with CMBP were performed.

상단으로