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  • 08월 28일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Enantioselective Recognition of Amino Alcohols and Acids by Pyrrole and Imidazole based Binol Receptors

등록일
2008년 8월 11일 15시 56분 32초
접수번호
0626
발표코드
34P183포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅲ>
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
Raju Nandhakumar, 김관묵1
이화여자대학교 화학과, India
1이화여자대학교 화학과, Korea
Pure enantiomers of chiral amino alcohols and amino acids are useful as intermediates for producing a wide variety of biologically active molecules and also as chiral pool in ligand design for stereoselective catalysts. In the past decades, there have been a number of publications on developing enantioselective receptors for amines, amino alcohols and amino acids. Most of these studies are mainly based on noncovalent interactions such as hydrogen bonding, metal coordination and hydrophobic interactions. We designed and synthesized novel pyrrole and imidazole based Chiral Binol receptors, which can discriminate various 1,2-amino alcohols by Reversible Imine formation with internal Resonance Assisted Hydrogen Bonding (RAHB). One imine bond (Covalent Interaction), one RAHB to the imine nitrogen and two hydrogen bonds (from the heterocyles) to the alcoholic oxygen play an important role in the stereoselective recognition. The synthetic details of these receptors and the recognition properties will be presented.

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